- Maria Nicola Rosetti, aka Nurse Niki, a nightshift pediatric intensive care unit (PICU) nurse, and the narrator of this blog
- Maddie, Niki’s daughter
- Simon, Niki’s husband & Maddie’s father
- Liz, a nightshift nurse coworker of Niki’s in the PICU
- Kathy, another nightshift nurse PICU coworker
- Kris, a dayshift PICU nurse coworker of Niki’s
- Gerald, the nightshift respiratory therapist assigned to PICU
- Corey, the nightshift ER nurse
- Dr. Polk, the PICU intensivist
- Raquel, Niki’s sister
- Grant, Raquel’s husband, an attorney
- Amber, Simon’s wife
- Wade, Amber’s young son
The Adventures of Nurse Niki 
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